Effects of Aquatic Exercise on Vestibulo-motor and Expression of GAP-43 in Diffuse brain Injury Rats

The purposes of this study were to examine whether aquatic exercise has influence on the neuroplasticity and vestibulo-motor function in diffuse brain injury rats. 80 Sprague-Dawley rats were assigned to four groups; Group I: control group (n=20), Group II: aquatic exercise (n=20), Group III: treadmill exercise with change of velocity and inclination (n=20), Group IV: simple treadmill exercise (n=20). And we applied exercise each groups for 3 weeks except Group I. Before the rats were sacrificed to identify immunohistochemistry study at each time of measurement day, Rota-Rod test was given to assess changes in vestibulomotor function. then, the immunohistochemistry study of GAP-43 in discrete regions of the rat brain was performed to measure changes in neuroplasticity. The results demonstrate that aquatic exercise group is more effective than other groups. expression of GAP-43 and vestibulo-motor function were increased most in aquatic exercise group. Therefore, this study suggest that aquatic exercise may effective therapeutic approach to increase neuroplasticity and vestibulo-motor function in traumatic brain injury. ■ keyword :∣Aquatic Exercise∣Diffuse Brain Injury∣GAP-43∣ 접수번호 : #091030-007 접수일자 : 2009년 10월 30일 심사완료일 : 2009년 12월 14일 교신저자 : 양승훈, e-mail : [email protected] 수중운동이 미만성 뇌손상 백서의 전정-운동 및 GAP-43 발현에 미치는 영향 657